Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Elise C. Cope; Samantha H. Wang; Renée C. Waters; Isha R. Gore; Betsy Vasquez; Blake J. Laham; Elizabeth Gould

doi:10.1038/s41467-023-37248-8

Nature Communications (Mar 2023)

Activation of the CA2-ventral CA1 pathway reverses social discrimination dysfunction in Shank3B knockout mice

Elise C. Cope,
Samantha H. Wang,
Renée C. Waters,
Isha R. Gore,
Betsy Vasquez,
Blake J. Laham,
Elizabeth Gould

Affiliations

Elise C. Cope: Princeton Neuroscience Institute, Princeton University
Samantha H. Wang: Princeton Neuroscience Institute, Princeton University
Renée C. Waters: Princeton Neuroscience Institute, Princeton University
Isha R. Gore: Princeton Neuroscience Institute, Princeton University
Betsy Vasquez: Princeton Neuroscience Institute, Princeton University
Blake J. Laham: Princeton Neuroscience Institute, Princeton University
Elizabeth Gould: Princeton Neuroscience Institute, Princeton University

DOI: https://doi.org/10.1038/s41467-023-37248-8
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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The SHANK3 gene is linked to autism spectrum disorder and Phelan McDermid syndrome, which have been associated with social memory deficits. Here, authors show activation of the hippocampal CA2-ventral CA1 circuit in adult Shank3B knockout mice restores social memory.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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