Nature Communications (Mar 2022)
UBR4/POE facilitates secretory trafficking to maintain circadian clock synchrony
- Sara Hegazi,
- Arthur H. Cheng,
- Joshua J. Krupp,
- Takafumi Tasaki,
- Jiashu Liu,
- Daniel A. Szulc,
- Harrod H. Ling,
- Julian Rios Garcia,
- Shavanie Seecharran,
- Tayebeh Basiri,
- Mehdi Amiri,
- Zobia Anwar,
- Safa Ahmad,
- Kamar Nayal,
- Nahum Sonenberg,
- Bao-Hua Liu,
- Hai-Ling Margaret Cheng,
- Joel D. Levine,
- Hai-Ying Mary Cheng
Affiliations
- Sara Hegazi
- Department of Biology, University of Toronto Mississauga
- Arthur H. Cheng
- Department of Biology, University of Toronto Mississauga
- Joshua J. Krupp
- Department of Biology, University of Toronto Mississauga
- Takafumi Tasaki
- Division of Protein Regulation Research, Medical Research Institute, Kanazawa Medical University
- Jiashu Liu
- Department of Biology, University of Toronto Mississauga
- Daniel A. Szulc
- Institute of Biomedical Engineering, University of Toronto
- Harrod H. Ling
- Department of Biology, University of Toronto Mississauga
- Julian Rios Garcia
- Department of Biology, University of Toronto Mississauga
- Shavanie Seecharran
- Department of Biology, University of Toronto Mississauga
- Tayebeh Basiri
- Department of Biochemistry, Goodman Cancer Research Center, McGill University
- Mehdi Amiri
- Department of Biochemistry, Goodman Cancer Research Center, McGill University
- Zobia Anwar
- Department of Biology, University of Toronto Mississauga
- Safa Ahmad
- Department of Biology, University of Toronto Mississauga
- Kamar Nayal
- Department of Biology, University of Toronto Mississauga
- Nahum Sonenberg
- Department of Biochemistry, Goodman Cancer Research Center, McGill University
- Bao-Hua Liu
- Department of Biology, University of Toronto Mississauga
- Hai-Ling Margaret Cheng
- Institute of Biomedical Engineering, University of Toronto
- Joel D. Levine
- Department of Biology, University of Toronto Mississauga
- Hai-Ying Mary Cheng
- Department of Biology, University of Toronto Mississauga
- DOI
- https://doi.org/10.1038/s41467-022-29244-1
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 21
Abstract
Although ubiquitin ligases are known to control clock protein degradation, their other roles in clock neurons are unclear. Here the authors report that UBR4 promotes export of neuropeptides from the Golgi for axonal trafficking, which is important for circadian clock synchrony in mice and flies.
