Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Hongsheng Zhang; Eunchai Kang; Yaqing Wang; Chaojuan Yang; Hui Yu; Qin Wang; Zheyu Chen; Chen Zhang; Kimberly M. Christian; Hongjun Song; Guo-li Ming; Zhiheng Xu

doi:10.1038/ncomms11773

Nature Communications (Jun 2016)

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Hongsheng Zhang,
Eunchai Kang,
Yaqing Wang,
Chaojuan Yang,
Hui Yu,
Qin Wang,
Zheyu Chen,
Chen Zhang,
Kimberly M. Christian,
Hongjun Song,
Guo-li Ming,
Zhiheng Xu

Affiliations

Hongsheng Zhang: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Eunchai Kang: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Yaqing Wang: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Chaojuan Yang: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University
Hui Yu: Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University
Qin Wang: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences
Zheyu Chen: Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University
Chen Zhang: State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University
Kimberly M. Christian: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Hongjun Song: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Guo-li Ming: Institute for Cell Engineering, Johns Hopkins University School of Medicine
Zhiheng Xu: State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/ncomms11773
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 11

Abstract

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The in vivo function of CRMP2 is unclear. Zhang et al. generate and characterize brain-specific Crmp2knockout mice. These mice show impairments in hippocampal neurogenesis, neuronal maturation and synaptic transmission, and exhibit schizophrenia-related behavioral deficits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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