An investigation of causal relationships between prediabetes and vascular complications

Pascal M. Mutie; Hugo Pomares-Millan; Naeimeh Atabaki-Pasdar; Nina Jordan; Rachel Adams; Nicole L. Daly; Juan Fernandes Tajes; Giuseppe N. Giordano; Paul W. Franks

doi:10.1038/s41467-020-18386-9

Nature Communications (Sep 2020)

An investigation of causal relationships between prediabetes and vascular complications

Pascal M. Mutie,
Hugo Pomares-Millan,
Naeimeh Atabaki-Pasdar,
Nina Jordan,
Rachel Adams,
Nicole L. Daly,
Juan Fernandes Tajes,
Giuseppe N. Giordano,
Paul W. Franks

Affiliations

Pascal M. Mutie: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital
Hugo Pomares-Millan: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital
Naeimeh Atabaki-Pasdar: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital
Nina Jordan: Regulatory Affairs Intelligence, Novo Nordisk A/S
Rachel Adams: Regulatory Affairs—Neuroscience and Cardiovascular Metabolism, Janssen
Nicole L. Daly: Regulatory Affairs—Neuroscience and Cardiovascular Metabolism, Janssen
Juan Fernandes Tajes: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital
Giuseppe N. Giordano: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital
Paul W. Franks: Genetic and Molecular Epidemiology Unit, Lund University Diabetes Centre, Department of Clinical Sciences, Clinical Research Centre, Lund University, Skåne University Hospital

DOI: https://doi.org/10.1038/s41467-020-18386-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 11

Abstract

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Prediabetes has been associated with diabetes complications, but these relationships may be confounded. Here the authors show, using genetic data in causal inference analyses, that prediabetes raises risk of coronary heart disease, but not other diabetes complications.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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