HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications

Abstract

HPF1 controls the ADP-ribosylation activity of PARP1/2 in response to DNA breaks. Here, the authors show that HPF1 regulates the balance between ADP-ribose initiation and elongation through a dynamic interaction that accelerates the initiation rate on serine residues.