The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Anne E. Geller; Rejeena Shrestha; Matthew R. Woeste; Haixun Guo; Xiaoling Hu; Chuanlin Ding; Kalina Andreeva; Julia H. Chariker; Mingqian Zhou; David Tieri; Corey T. Watson; Robert A. Mitchell; Huang-ge Zhang; Yan Li; Robert C. G. Martin II; Eric C. Rouchka; Jun Yan

doi:10.1038/s41467-022-28407-4

Nature Communications (Feb 2022)

The induction of peripheral trained immunity in the pancreas incites anti-tumor activity to control pancreatic cancer progression

Anne E. Geller,
Rejeena Shrestha,
Matthew R. Woeste,
Haixun Guo,
Xiaoling Hu,
Chuanlin Ding,
Kalina Andreeva,
Julia H. Chariker,
Mingqian Zhou,
David Tieri,
Corey T. Watson,
Robert A. Mitchell,
Huang-ge Zhang,
Yan Li,
Robert C. G. Martin II,
Eric C. Rouchka,
Jun Yan

Affiliations

Anne E. Geller: Department of Microbiology and Immunology, University of Louisville
Rejeena Shrestha: Department of Microbiology and Immunology, University of Louisville
Matthew R. Woeste: Department of Microbiology and Immunology, University of Louisville
Haixun Guo: Department of Radiology, University of Louisville
Xiaoling Hu: Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville
Chuanlin Ding: Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville
Kalina Andreeva: Department of Anatomical Sciences and Neurobiology, University of Louisville
Julia H. Chariker: Department of Anatomical Sciences and Neurobiology, University of Louisville
Mingqian Zhou: Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville
David Tieri: Department of Biochemistry and Molecular Genetics, University of Louisville
Corey T. Watson: Department of Biochemistry and Molecular Genetics, University of Louisville
Robert A. Mitchell: Division of Immunotherapy, The Hiram C. Polk, Jr., MD Department of Surgery, Immuno-Oncology Program, Brown Cancer Center, University of Louisville
Huang-ge Zhang: Department of Microbiology and Immunology, University of Louisville
Yan Li: Division of Surgical Oncology, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville
Robert C. G. Martin II: Division of Surgical Oncology, The Hiram C. Polk, Jr., MD Department of Surgery, University of Louisville
Eric C. Rouchka: Kentucky Biomedical Research Infrastructure Network Bioinformatics Core, University of Louisville
Jun Yan: Department of Microbiology and Immunology, University of Louisville

DOI: https://doi.org/10.1038/s41467-022-28407-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 20

Abstract

Read online

The advent of immunotherapy has revolutionised cancer therapeutics, but its application in the context of pancreatic ductal adenocarcinoma has been limited. Here authors explore the effect of innate trained responses to fungal β-glucan and assess its effect in a murine model of pancreatic ductal adenocarcinoma where they observe reduced tumour burden and enhanced survival.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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