Nature Communications (May 2021)
Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis
Abstract
Cancer metastasis is the leading cause of death in patients, here, the authors show disrupting tumor vasculature could recruit and activate anti-PD-L1 engineered platelet at metastatic tumor sites to block the PD-1/PD-L1 crosstalk and enhance the anticancer immunotherapy.