European Journal of Case Reports in Internal Medicine (Aug 2022)

Pulmonary Nocardiosis as an Opportunistic Infection in COVID-19

  • Marc Laplace,
  • Thomas Flamand,
  • Ciprian Ion,
  • Simon Gravier,
  • Mahsa Mohseni-Zadeh,
  • Dominique Debriel,
  • Olivier Augereau,
  • Guillaume Gregorowicz,
  • Martin Martinot

DOI
https://doi.org/10.12890/2022_003477

Abstract

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Secondary bacterial pneumonia infection is frequent in COVID-19 patients. Nocardia are responsible for opportunistic pulmonary infections especially after steroid treatment. We describe a case of pulmonary nocardiosis following critical COVID-19 pneumonia in an 83-year-old male. Two weeks after initiation of dexamethasone 6 mg/L, the patient developed a new episode of acute dyspnea. The sputum cultures identified Nocardia cyriacigeorgica. In spite of intravenous imipenem and cotrimoxazole treatment the patient died. Physicians should be aware of the possibility of nocardiosis in case of deterioration of respiratory status of severe COVID-19 inpatients and perform Nocardia evaluation. This evaluation requires prolonged culture.

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