Nature Communications (Jul 2020)
IgCaller for reconstructing immunoglobulin gene rearrangements and oncogenic translocations from whole-genome sequencing in lymphoid neoplasms
- Ferran Nadeu,
- Rut Mas-de-les-Valls,
- Alba Navarro,
- Romina Royo,
- Silvia Martín,
- Neus Villamor,
- Helena Suárez-Cisneros,
- Rosó Mares,
- Junyan Lu,
- Anna Enjuanes,
- Alfredo Rivas-Delgado,
- Marta Aymerich,
- Tycho Baumann,
- Dolors Colomer,
- Julio Delgado,
- Ryan D. Morin,
- Thorsten Zenz,
- Xose S. Puente,
- Peter J. Campbell,
- Sílvia Beà,
- Francesco Maura,
- Elías Campo
Affiliations
- Ferran Nadeu
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Rut Mas-de-les-Valls
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Alba Navarro
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Romina Royo
- Barcelona Supercomputing Center (BSC)
- Silvia Martín
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Neus Villamor
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Helena Suárez-Cisneros
- Unitat de Genòmica, IDIBAPS
- Rosó Mares
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Junyan Lu
- European Molecular Biology Laboratory (EMBL)
- Anna Enjuanes
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Alfredo Rivas-Delgado
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Marta Aymerich
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Tycho Baumann
- Hospital Clínic of Barcelona
- Dolors Colomer
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Julio Delgado
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Ryan D. Morin
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Thorsten Zenz
- Department of Medical Oncology and Hematology, University Hospital and University of Zürich
- Xose S. Puente
- Centro de Investigación Biomédica en Red de Cáncer (CIBERONC)
- Peter J. Campbell
- Wellcome Sanger Institute, Hinxton
- Sílvia Beà
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- Francesco Maura
- Wellcome Sanger Institute, Hinxton
- Elías Campo
- Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
- DOI
- https://doi.org/10.1038/s41467-020-17095-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Immunoglobulin (Ig) rearrangement and translocation information are usually obtained by targeted sequencing of the respective loci. Here, the authors present the IgCaller algorithm, which extracts Ig heavy and light chain genetic properties from short-read whole-genome sequencing results to provide a feasible alternative to direct sequencing.
