Nature Communications (Sep 2017)
Mitochondrial mutations drive prostate cancer aggression
- Julia F. Hopkins,
- Veronica Y. Sabelnykova,
- Joachim Weischenfeldt,
- Ronald Simon,
- Jennifer A. Aguiar,
- Rached Alkallas,
- Lawrence E. Heisler,
- Junyan Zhang,
- John D. Watson,
- Melvin L. K. Chua,
- Michael Fraser,
- Francesco Favero,
- Chris Lawerenz,
- Christoph Plass,
- Guido Sauter,
- John D. McPherson,
- Theodorus van der Kwast,
- Jan Korbel,
- Thorsten Schlomm,
- Robert G. Bristow,
- Paul C. Boutros
Affiliations
- Julia F. Hopkins
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Veronica Y. Sabelnykova
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Joachim Weischenfeldt
- Genome Biology Unit, European Molecular Biology Laboratory
- Ronald Simon
- Institute of Pathology, University Medical Center Hamburg-Eppendorf
- Jennifer A. Aguiar
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Rached Alkallas
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Lawrence E. Heisler
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Junyan Zhang
- Princess Margaret Cancer Centre, University Health Network
- John D. Watson
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- Melvin L. K. Chua
- Princess Margaret Cancer Centre, University Health Network
- Michael Fraser
- Princess Margaret Cancer Centre, University Health Network
- Francesco Favero
- Biotech Research & Innovation Centre (BRIC) and Finsen Laboratory
- Chris Lawerenz
- Division of Theoretical Bioinformatics, German Cancer Research Center
- Christoph Plass
- Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center
- Guido Sauter
- Institute of Pathology, University Medical Center Hamburg-Eppendorf
- John D. McPherson
- Genome Technologies Program, Ontario Institute for Cancer Research
- Theodorus van der Kwast
- Department of Pathology and Laboratory Medicine, Toronto General Hospital/University Health Network
- Jan Korbel
- Genome Biology Unit, European Molecular Biology Laboratory
- Thorsten Schlomm
- Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf
- Robert G. Bristow
- Princess Margaret Cancer Centre, University Health Network
- Paul C. Boutros
- Informatics and Biocomputing Program, Ontario Institute for Cancer Research
- DOI
- https://doi.org/10.1038/s41467-017-00377-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 8
Abstract
In prostate cancer, the role of mutations in the maternally-inherited mitochondrial genome are not well known. Here, the authors demonstrate frequent, age-dependent mitochondrial mutation in prostate cancer. Strong links between mitochondrial and nuclear mutational profiles are associated with clinical aggressivity.
