Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Yun Qian; Yun Qian; Qixin Han; Wei Chen; Wei Chen; Jialin Song; Jialin Song; Xiaotian Zhao; Yuanming Ouyang; Yuanming Ouyang; Weien Yuan; Cunyi Fan

doi:10.3389/fchem.2017.00089

Frontiers in Chemistry (Oct 2017)

Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

Yun Qian,
Yun Qian,
Qixin Han,
Wei Chen,
Wei Chen,
Jialin Song,
Jialin Song,
Xiaotian Zhao,
Yuanming Ouyang,
Yuanming Ouyang,
Weien Yuan,
Cunyi Fan

Affiliations

Yun Qian: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
Yun Qian: Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, China
Qixin Han: Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Wei Chen: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
Wei Chen: Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, China
Jialin Song: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
Jialin Song: Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, China
Xiaotian Zhao: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
Yuanming Ouyang: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China
Yuanming Ouyang: Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health, Shanghai, China
Weien Yuan: School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
Cunyi Fan: Department of Orthopedics, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China

DOI: https://doi.org/10.3389/fchem.2017.00089
Journal volume & issue: Vol. 5

Abstract

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Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

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