Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway

Abstract

Highlights 1. Kisspeptin expression is decreased in ovaries of PCOS rat 2. Kisspeptin promotes proliferation and inhibits apoptosis of granulosa cells 3. Kisspeptin alleviates oxidative stress of granulosa cells 4. Kisspeptin activates PI3K/AKT/ERK signalling pathway

Keywords

• Kisspeptin
• Polycystic ovary syndrome
• Granulosa cell
• Oxidative stress
• Apoptosis
• PI3K/AKT/ERK signalling