Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

Abdelaaty Hamed; Ahmed S. Abdel-Razek; Marcel Frese; Hans Georg Stammler; Atef F. El-Haddad; Tarek M. A. Ibrahim; Norbert Sewald; Mohamed Shaaban

doi:10.3390/molecules23020299

Molecules (Jan 2018)

Terretonin N: A New Meroterpenoid from Nocardiopsis sp.

Abdelaaty Hamed,
Ahmed S. Abdel-Razek,
Marcel Frese,
Hans Georg Stammler,
Atef F. El-Haddad,
Tarek M. A. Ibrahim,
Norbert Sewald,
Mohamed Shaaban

Affiliations

Abdelaaty Hamed: Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Ahmed S. Abdel-Razek: Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Marcel Frese: Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Hans Georg Stammler: Department of Chemistry, Inorganic and Structural Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Atef F. El-Haddad: Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt
Tarek M. A. Ibrahim: Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City-Cairo 11884, Egypt
Norbert Sewald: Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
Mohamed Shaaban: Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany

DOI: https://doi.org/10.3390/molecules23020299
Journal volume & issue: Vol. 23, no. 2
p. 299

Abstract

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Terretonin N (1), a new highly oxygenated and unique tetracyclic 6-hydroxymeroterpenoid, was isolated together with seven known compounds from the ethyl acetate extract of a solid-state fermented culture of Nocardiopsis sp. Their structures were elucidated by spectroscopic analysis. The structure and absolute configuration of 1 were unambiguously determined by X-ray crystallography. The isolation and taxonomic characterization of Nocardiopsis sp. is reported. The antimicrobial activity and cytotoxicity of the strain extract and compound 1 were studied using different microorganisms and a cervix carcinoma cell line, respectively.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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