CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation

Motoko Y. Kimura; Akemi Igi; Koji Hayashizaki; Yukiyoshi Mita; Miho Shinzawa; Tejas Kadakia; Yukihiro Endo; Satomi Ogawa; Ryoji Yagi; Shinichiro Motohashi; Alfred Singer; Toshinori Nakayama

doi:10.1038/s41467-018-06283-1

Nature Communications (Sep 2018)

CD69 prevents PLZFhi innate precursors from prematurely exiting the thymus and aborting NKT2 cell differentiation

Motoko Y. Kimura,
Akemi Igi,
Koji Hayashizaki,
Yukiyoshi Mita,
Miho Shinzawa,
Tejas Kadakia,
Yukihiro Endo,
Satomi Ogawa,
Ryoji Yagi,
Shinichiro Motohashi,
Alfred Singer,
Toshinori Nakayama

Affiliations

Motoko Y. Kimura: Department of Immunology, Graduate School of Medicine, Chiba University
Akemi Igi: Department of Immunology, Graduate School of Medicine, Chiba University
Koji Hayashizaki: Department of Immunology, Graduate School of Medicine, Chiba University
Yukiyoshi Mita: Department of Immunology, Graduate School of Medicine, Chiba University
Miho Shinzawa: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
Tejas Kadakia: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
Yukihiro Endo: Department of Immunology, Graduate School of Medicine, Chiba University
Satomi Ogawa: Department of Immunology, Graduate School of Medicine, Chiba University
Ryoji Yagi: Department of Immunology, Graduate School of Medicine, Chiba University
Shinichiro Motohashi: Department of Medical Immunology, Graduate School of Medicine, Chiba University
Alfred Singer: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health
Toshinori Nakayama: Department of Immunology, Graduate School of Medicine, Chiba University

DOI: https://doi.org/10.1038/s41467-018-06283-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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CD69 competes with S1P1, a chemokine receptor mediating thymocyte egress, for surface expression on thymocytes, but whether CD69 is required for normal thymic development is unclear. Here the authors show that CD69 and S1P1 synergize to control type 2 natural killer (NKT2) cells differentiation by modulating the thymic egress of NKT2 precursor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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