Vіsnik Naukovih Doslіdžen' (Apr 2017)
THE INFLUENCE OF WATER NEGATIVE REDOX POTENTIAL ON RENAL FUNCTION IN OLIGURIA STAGE SUBLIMATE NEPHROPATHY
Abstract
It is known that the reducing the redox potential of water for every 59 mV results in increased number of electrons in 10 times. The aim of the study – to determine the effect of the load by water negative redox potential for the indicators of renal function compared with induced diuresis with normal tap water in olyguria stage of sublimate nephropathy. Materials and Methods. In experiments on 40 white nonlinear mature rats-males in olyguria stage of sublimate nephropathy, which was modeled in terms of hyponatriume diet by subcutaneous injection of mercuric chloride at a dose of 5 mg/kg, with a load of water negative redox potential (-232.0±to 25.12 mV) compared with induced diuresis with normal tap water (oxidation-reduction potential 88.7±18.35 mV), which was measured ORP meter, we researched, excretory, ionoregulatory and acid regulating of kidney function. Results and Discussion. According to the experience the inhibition of diuresis and the relative diuresis, because of the improvement of the reabsorption of ions of sodium in the proximal and distal tubules by increasing the supply of electrons to the tubules of the kidneys. This provision confirmed using multivariate regression analysis because of a tendency to increase the distal and proximal reabsorption of sodium ions led to a decrease in syndrome loss of sodium ions from urine with the trend of increase of its concentration in blood plasma with the establishment of reliable correlative relationships (p< 0.05) between the above-mentioned indicators. Improving the energy status of the proximal nephron under conditions of experience have led to improved reabsorption of protein and reducing its excretion in the urine. As a result of these changes was a reduction in the supply of sodium ions to the macula densa of the distal nephron, inhibition tubulo-glomerular feedback with a reduction of reactivity of the renin-angiotensin-aldosterone system and decrease in concentration and excretion of potassium ions in the urine. The reduction of urinary excretion of ammonia due to alkaline properties microhydrine, which caused inhibition of amonagement, which typically is activated when uncompensated acidosis.
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