Reacción similar a la enfermedad del suero secundaria al uso de cefalotina: reporte de un caso

Abstract

Serum sickness (SS) and SS-like reactions (SSLR) are indistinguishable clinical entities but with different pathophysiological processes, particularly regarding its impact on the complement system. The VigiAccess™ database contains only 3 potential SS cases out of 2,890 records for cephalothin reported between 1968 and December 2021, but none for SSLR. This commonly used antibiotic was approved in 1974, and its first clinical studies described that all healthy volunteers could produce SSLR depending on the dose and infusion rate. Here we have the case of a young woman, previously healthy, who suffered an ophidian accident receiving both antivenom and cephalothin, in consequence she developed an apparent SS requiring re-hospitalization, because there was no complement activation and consumption, her recovery was complete and uncomplicated, it was defined as a probable SSLR.

Keywords

• serum sickness
• drug-related side effects and adverse reactions
• case report