Nature Communications (Jul 2021)

α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation

  • Xuan Xie,
  • Shaogang Wang,
  • Mingyi Li,
  • Lei Diao,
  • Xingyu Pan,
  • Jijun Chen,
  • Weiguo Zou,
  • Xu Zhang,
  • Wenfeng Feng,
  • Lan Bao

DOI
https://doi.org/10.1038/s41467-021-24376-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Post-translational modifications of tubulins regulate microtubule properties and neural development. Here, the authors report that one such post-translational modification, α-TubK40me3, is required for neuronal polarization and migration by promoting microtubule formation.