Cellular Oncology (Jan 2010)

Novel In Vitro Assays for the Characterization of EMT in Tumourigenesis

  • Vincent Koo,
  • Amgad El Mekabaty,
  • Peter Hamilton,
  • Perry Maxwell,
  • Osama Sharaf,
  • Jim Diamond,
  • Jenny Watson,
  • Kathleen Williamson

DOI
https://doi.org/10.3233/CLO-2009-0501
Journal volume & issue
Vol. 32, no. 1-2
pp. 67 – 76

Abstract

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Background: Two novel assays quantifying Epithelial to Mesenchymal Transition (EMT) were compared to traditional motility and migration assays. TGF-β1 treatment of AY-27 rat bladder cancer cells acted as a model of EMT in tumourigenesis.