The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

Ismail Nurul Iman; Nurul Aiman Mohd Yusof; Ummi Nasrah Talib; Nur Aimi Zawami Ahmad; Anwar Norazit; Jaya Kumar; Muhammad Zulfadli Mehat; Nanthini Jayabalan; Sangu Muthuraju; Marzena Stefaniuk; Leszek Kaczmarek; Mustapha Muzaimi

doi:10.3389/fnbeh.2021.683780

Frontiers in Behavioral Neuroscience (Jun 2021)

The IntelliCage System: A Review of Its Utility as a Novel Behavioral Platform for a Rodent Model of Substance Use Disorder

Ismail Nurul Iman,
Nurul Aiman Mohd Yusof,
Ummi Nasrah Talib,
Nur Aimi Zawami Ahmad,
Anwar Norazit,
Jaya Kumar,
Muhammad Zulfadli Mehat,
Nanthini Jayabalan,
Sangu Muthuraju,
Marzena Stefaniuk,
Leszek Kaczmarek,
Mustapha Muzaimi

Affiliations

Ismail Nurul Iman: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Nurul Aiman Mohd Yusof: Department of Anatomy, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Ummi Nasrah Talib: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Nur Aimi Zawami Ahmad: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia
Anwar Norazit: Department of Biomedical Sciences, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia
Jaya Kumar: Department of Physiology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Muhammad Zulfadli Mehat: Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
Nanthini Jayabalan: Translational Neuroscience Lab, UQ Centre for Clinical Research, The University of Queensland, Brisbane, QLD, Australia
Sangu Muthuraju: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX, United States
Marzena Stefaniuk: BRAINCITY, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
Leszek Kaczmarek: BRAINCITY, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
Mustapha Muzaimi: Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia

DOI: https://doi.org/10.3389/fnbeh.2021.683780
Journal volume & issue: Vol. 15

Abstract

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The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model.

Published in Frontiers in Behavioral Neuroscience

ISSN: 1662-5153 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: http://www.frontiersin.org/behavioral_neuroscience

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