Small-molecule fluorescence-based probes for aging diagnosis

Donglei Shi; Wenwen Liu; Guangwei Wang; Yuan Guo; Jian Li

doi:10.15212/AMM-2021-0004

Acta Materia Medica (Jan 2022)

Small-molecule fluorescence-based probes for aging diagnosis

Donglei Shi,
Wenwen Liu,
Guangwei Wang,
Yuan Guo,
Jian Li

Affiliations

Donglei Shi: State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
Wenwen Liu: Key Laboratory of Tropical Biological Resources of Ministry of Education, College of Pharmacy, Hainan University, Haikou 570228, Hainan, China
Guangwei Wang: College of Chemistry and Materials Science, Northwest University, Xi’an 710127, China
Yuan Guo: College of Chemistry and Materials Science, Northwest University, Xi’an 710127, China
Jian Li: State Key Laboratory of Bioreactor Engineering, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

DOI: https://doi.org/10.15212/AMM-2021-0004
Journal volume & issue: Vol. 1, no. 1
pp. 4 – 23

Abstract

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Aging is a time-dependent decline in physiological function that affects most organisms and is the major risk factor for many non-communicable diseases. The early diagnosis of aging is critical for the treatment of aging and aging-related diseases. In recent years, extensive efforts have attempted to accurately diagnose aging. To date, multiple types of fluorescent probes for various age-related biomarkers have been developed, with the aims of achieving rapid, precise diagnosis of the aging process and evaluating the efficacy of anti-aging drugs. This review summarizes recent research progress in small-molecule fluorescence-based probes for aging diagnosis, and further discusses the challenges and opportunities in this field.

Published in Acta Materia Medica

ISSN: 2737-7946 (Online)
Publisher: Compuscript Ltd
Country of publisher: Ireland
LCC subjects: Medicine: Pharmacy and materia medica; Medicine: Therapeutics. Pharmacology
Website: https://amm-journal.org/

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