生物医学转化 (Jun 2022)

Clinical efficacy observation of yinqiao qingre tablet

  • Wu Shengxian,
  • Fan Qinhua,
  • Su Wenquan,
  • Zhang Lishan,
  • Zhang Wei,
  • Fang Bangjiang,
  • Zhou Ling,
  • Long Youyu,
  • Zhang Yeqing,
  • Wang Tan,
  • Xiong Xudong,
  • Qu Nini,
  • Shi Kehua,
  • Xiao Wei,
  • Shang Hongcai,
  • Wang Yongyan

DOI
https://doi.org/10.12287/j.issn.2096-8965.20220312
Journal volume & issue
Vol. 3, no. 2
pp. 82 – 92

Abstract

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Objective To evaluate the efficacy and safety of yinqiao qingre tablet in treating common cold with wind-heat type.Methods The randomized, double-blind, placebo, parallel control research were applied to this study. The eligible subjects were divided into a experimental group, a positive control group and a placebo control group. The test drug was yinqiao qingre tablet, positive control drug was yinqiao jiedu tablet, and simulation drugs were yinqiao qingre simulation tablet and yinqiao jiedu simulation tablet. The experimental group was given yinqiao qingre tablet and yinqiao jiedu simulation tablet, the positive control group was given yinqiao qingre simulation tablet and yinqiao jiedu tablet, and the placebo control group was given yinqiao qingre simulation tablet and yinqiao jiedu simulation tablet.The course of treatment for each group was 3 days. Before and after treatment, the disappearance rate of major symptoms, individual symptom scores, efficacy of TCM syndrome, change of temperature, used of antipyretic analgesics and safety were evaluated. Results The disappearance rate of major symptoms was 62.12% in experimental group, was the highest among three groups(P<0.01). After treatment, individual symptom scores of the three groups all descended(P<0.01). In experimental group, the individual symptom scores decreased the most, and the disappearance rate was the highest(P<0.01). The efficacy rate of TCM syndrome was 94.99%, TCM efficacy rate of experimental group was the highest among three groups(P<0.01). Temperature of three groups all descended. In experimental group, the beginning drop time was 8 hours and the returning normal time was 20 hours, experimental group was was shortest among three groups (P<0.01). The use rate of antipyretic analgesics was 0.28% in experimental group,and was the least among three groups(P<0.01). There were no serious adverse events and reactions in the three groups. Conclusion Yinqiao qingre tablet has satisfactory effects and safety on common cold with wind-heat type.

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