Nature Communications (Mar 2021)
Bacterial cyclic diguanylate signaling networks sense temperature
- Henrik Almblad,
- Trevor E. Randall,
- Fanny Liu,
- Katherine Leblanc,
- Ryan A. Groves,
- Weerayuth Kittichotirat,
- Geoffrey L. Winsor,
- Nicolas Fournier,
- Emily Au,
- Julie Groizeleau,
- Jacquelyn D. Rich,
- Yuefei Lou,
- Elise Granton,
- Laura K. Jennings,
- Larissa A. Singletary,
- Tara M. L. Winstone,
- Nathan M. Good,
- Roger E. Bumgarner,
- Michael F. Hynes,
- Manu Singh,
- Maria Silvina Stietz,
- Fiona S. L. Brinkman,
- Ayush Kumar,
- Ann Karen Cornelia Brassinga,
- Matthew R. Parsek,
- Boo Shan Tseng,
- Ian A. Lewis,
- Bryan G. Yipp,
- Justin L. MacCallum,
- Joe Jonathan Harrison
Affiliations
- Henrik Almblad
- Department of Biological Sciences, University of Calgary
- Trevor E. Randall
- Department of Biological Sciences, University of Calgary
- Fanny Liu
- Department of Biological Sciences, University of Calgary
- Katherine Leblanc
- Department of Biological Sciences, University of Calgary
- Ryan A. Groves
- Department of Biological Sciences, University of Calgary
- Weerayuth Kittichotirat
- Systems Biology and Bioinformatics Research Group, Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi
- Geoffrey L. Winsor
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Nicolas Fournier
- Department of Biological Sciences, University of Calgary
- Emily Au
- Department of Biological Sciences, University of Calgary
- Julie Groizeleau
- Department of Biological Sciences, University of Calgary
- Jacquelyn D. Rich
- Department of Biological Sciences, University of Calgary
- Yuefei Lou
- Cumming School of Medicine, University of Calgary
- Elise Granton
- Cumming School of Medicine, University of Calgary
- Laura K. Jennings
- Department of Microbiology, University of Washington
- Larissa A. Singletary
- Department of Microbiology, University of Washington
- Tara M. L. Winstone
- Department of Chemistry, University of Calgary
- Nathan M. Good
- Department of Microbiology, University of Washington
- Roger E. Bumgarner
- Department of Microbiology, University of Washington
- Michael F. Hynes
- Department of Biological Sciences, University of Calgary
- Manu Singh
- Department of Microbiology, University of Manitoba
- Maria Silvina Stietz
- Cumming School of Medicine, University of Calgary
- Fiona S. L. Brinkman
- Department of Molecular Biology and Biochemistry, Simon Fraser University
- Ayush Kumar
- Department of Microbiology, University of Manitoba
- Ann Karen Cornelia Brassinga
- Department of Microbiology, University of Manitoba
- Matthew R. Parsek
- Department of Microbiology, University of Washington
- Boo Shan Tseng
- School of Life Sciences, University of Nevada Las Vegas
- Ian A. Lewis
- Department of Biological Sciences, University of Calgary
- Bryan G. Yipp
- Cumming School of Medicine, University of Calgary
- Justin L. MacCallum
- Department of Chemistry, University of Calgary
- Joe Jonathan Harrison
- Department of Biological Sciences, University of Calgary
- DOI
- https://doi.org/10.1038/s41467-021-22176-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility, biofilm development and virulence in the opportunistic pathogen Pseudomonas aeruginosa.
