An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines

Yan Guo; Wenhui He; Huihui Mou; Lizhou Zhang; Jing Chang; Shoujiao Peng; Amrita Ojha; Rubens Tavora; Mark S. Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan; Brian D. Quinlan

doi:10.1128/mBio.00930-21

mBio (Jun 2021)

An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines

Yan Guo,
Wenhui He,
Huihui Mou,
Lizhou Zhang,
Jing Chang,
Shoujiao Peng,
Amrita Ojha,
Rubens Tavora,
Mark S. Parcells,
Guangxiang Luo,
Wenhui Li,
Guocai Zhong,
Hyeryun Choe,
Michael Farzan,
Brian D. Quinlan

Affiliations

Yan Guo: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Wenhui He: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Huihui Mou: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Lizhou Zhang: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Jing Chang: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Shoujiao Peng: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Amrita Ojha: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Rubens Tavora: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Mark S. Parcells: Department of Animal and Food Sciences, University of Delaware, Newark, Delaware, USA
Guangxiang Luo: ORCiD; Department of Microbiology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA
Wenhui Li: National Institute of Biological Sciences, Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China
Guocai Zhong: Scripps Research SZBL Chemical Biology Institute, Shenzhen Bay Laboratory, Shenzhen, China
Hyeryun Choe: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Michael Farzan: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA
Brian D. Quinlan: Department of Immunology and Microbiology, The Scripps Research Institute, Jupiter, Florida, USA

DOI: https://doi.org/10.1128/mBio.00930-21
Journal volume & issue: Vol. 12, no. 3

Abstract

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All available vaccines for coronavirus disease 2019 (COVID-19) express or deliver the full-length SARS-CoV-2 spike (S) protein. We show that this antigen is not optimal, consistent with observations that the vast majority of the neutralizing response to the virus is focused on the S-protein receptor-binding domain (RBD).

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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