Nature Communications (Nov 2018)
Pd(OAc)2-catalyzed asymmetric hydrogenation of sterically hindered N-tosylimines
Abstract
Sterically hindered unsaturated compounds are challenging substrates for asymmetric hydrogenation. Here, the authors report a palladium/chiral (bis)phosphine catalytic system that hydrogenates a number of hindered N-tosylimines with excellent enantioselectivitites.