Immune checkpoint silencing using RNAi-incorporated nanoparticles enhances antitumor immunity and therapeutic efficacy compared with antibody-based approaches

• Hee Dong Han,
• Tae Heung Kang,
• Yeong-Min Park,
• Jeong-Won Lee,
• Ji Eun Won,
• Youngseon Byeon,
• Tae In Wi,
• Chan Mi Lee,
• Ju Hyeong Lee,
• YoungJoo Lee

Affiliations

Hee Dong Han

Aff1 0000 0004 0532 8339grid.258676.8Department of Immunology, KU Open Innovation CenterSchool of Medicine, Konkuk University 268, Chungwondaero 274798 Chungju South Korea

Tae Heung Kang

Aff2 grid.411120.7000000040371843XImmunologyKonkuk University Medical Center Chungju Republic of Korea

Yeong-Min Park

Aff1 0000 0004 0532 8339grid.258676.8Department of Immunology, KU Open Innovation CenterSchool of Medicine, Konkuk University 268, Chungwondaero 274798 Chungju South Korea

Jeong-Won Lee

Obstetrics and Gynecology, and

Ji Eun Won

Department of Immunology, Konkuk University School of Medicine, Chungju, The Republic of Korea

Youngseon Byeon

Department of Immunology, Konkuk University School of Medicine, Chungju, The Republic of Korea

Tae In Wi

Department of Immunology, Konkuk University School of Medicine, Chungju, The Republic of Korea

Chan Mi Lee

Department of Immunology, Konkuk University School of Medicine, Chungju, The Republic of Korea

Ju Hyeong Lee

Department of Immunology, Konkuk University School of Medicine, Chungju, The Republic of Korea

YoungJoo Lee

Department of Integrative Bioscience and Biotechnology, Sejong University, Gwangjin-gu, The Republic of Korea