Synthesis and Bioactivity of a-Aminophosphonates Containing Fluorine

Abstract

Twenty-one a-aminophosphonates containing fluorine were synthesized by Mannich-type reactions. Their structures were established by elemental analysis, IR, 1H- NMR and MS. In field tests, some of these new compounds display high antiviral activity against the tobacco mosaic virus (TMV). The molecular geometry of compound 4f was determined by X-ray diffraction structure analysis.

Keywords

• a-Aminophosphonates
• synthesis
• bioactivity