Soluble Klotho protects against glomerular injury through regulation of ER stress response

Emmanuelle Charrin; Dina Dabaghie; Ilke Sen; David Unnersjö-Jess; Katja Möller-Hackbarth; Mikhail Burmakin; Rik Mencke; Sonia Zambrano; Jaakko Patrakka; Hannes Olauson

doi:10.1038/s42003-023-04563-1

Communications Biology (Feb 2023)

Soluble Klotho protects against glomerular injury through regulation of ER stress response

Emmanuelle Charrin,
Dina Dabaghie,
Ilke Sen,
David Unnersjö-Jess,
Katja Möller-Hackbarth,
Mikhail Burmakin,
Rik Mencke,
Sonia Zambrano,
Jaakko Patrakka,
Hannes Olauson

Affiliations

Emmanuelle Charrin: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Dina Dabaghie: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Ilke Sen: Division of Integrative Physiology, Department of Physiology and Pharmacology, Karolinska Institutet
David Unnersjö-Jess: Department II of Internal Medicine and Center for Molecular Medicine Cologne, University of Cologne, Faculty of Medicine and University Hospital Cologne
Katja Möller-Hackbarth: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Mikhail Burmakin: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Rik Mencke: Division of Pathology, Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen
Sonia Zambrano: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Jaakko Patrakka: KI/AZ Integrated Cardio Metabolic Center, Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge
Hannes Olauson: Division of Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet

DOI: https://doi.org/10.1038/s42003-023-04563-1
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 16

Abstract

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Transgenic overexpression of αKlotho in hepatocytes results in protection against renal insults, possibly through modulation of the ER stress response by circulating αKlotho. In contrast, αKlotho overexpressed in podocytes is not renoprotective.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal