Nature Communications (Nov 2020)

An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

  • Hanna Trzeciakiewicz,
  • Deepa Ajit,
  • Jui-Heng Tseng,
  • Youjun Chen,
  • Aditi Ajit,
  • Zarin Tabassum,
  • Rebecca Lobrovich,
  • Claire Peterson,
  • Natallia V. Riddick,
  • Michelle S. Itano,
  • Ashutosh Tripathy,
  • Sheryl S. Moy,
  • Virginia M. Y. Lee,
  • John Q. Trojanowski,
  • David J. Irwin,
  • Todd J. Cohen

DOI
https://doi.org/10.1038/s41467-020-19317-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 18

Abstract

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HDAC6 is a tau deacetylase and acetylation of tau inhibits its function and promotes aggregation. Here the authors show that HDAC6 protects against tau accumulation in a mouse model of tauopathy.