Nature Communications (Feb 2021)

Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer

  • Jeremy J. McGuire,
  • Jeremy S. Frieling,
  • Chen Hao Lo,
  • Tao Li,
  • Ayaz Muhammad,
  • Harshani R. Lawrence,
  • Nicholas J. Lawrence,
  • Leah M. Cook,
  • Conor C. Lynch

DOI
https://doi.org/10.1038/s41467-021-20962-6
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

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The effects of bone-marrow derived MSCs on prostate cancer cells remain unknown. Here the authors show that MSC-derived IL-28 induces prostate cancer cell apoptosis via IL-28Rα-STAT1 signalling, while acquired resistance to apoptosis is associated with a shift in IL-28Rα signalling via STAT1 to STAT3.