Nature Communications (Nov 2021)
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer
- Ming Chen,
- Runzhe Chen,
- Ying Jin,
- Jun Li,
- Xin Hu,
- Jiexin Zhang,
- Junya Fujimoto,
- Shawna M. Hubert,
- Carl M. Gay,
- Bo Zhu,
- Yanhua Tian,
- Nicholas McGranahan,
- Won-Chul Lee,
- Julie George,
- Xiao Hu,
- Yamei Chen,
- Meijuan Wu,
- Carmen Behrens,
- Chi-Wan Chow,
- Hoa H. N. Pham,
- Junya Fukuoka,
- Jia Wu,
- Edwin Roger Parra,
- Latasha D. Little,
- Curtis Gumbs,
- Xingzhi Song,
- Chang-Jiun Wu,
- Lixia Diao,
- Qi Wang,
- Robert Cardnell,
- Jianhua Zhang,
- Jing Wang,
- Xiuning Le,
- Don L. Gibbons,
- John V. Heymach,
- J. Jack Lee,
- William N. William,
- Chao Cheng,
- Bonnie Glisson,
- Ignacio Wistuba,
- P. Andrew Futreal,
- Roman K. Thomas,
- Alexandre Reuben,
- Lauren A. Byers,
- Jianjun Zhang
Affiliations
- Ming Chen
- Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University
- Runzhe Chen
- Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University
- Ying Jin
- The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
- Jun Li
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Xin Hu
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Jiexin Zhang
- Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center
- Junya Fujimoto
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Shawna M. Hubert
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Carl M. Gay
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Bo Zhu
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Yanhua Tian
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Nicholas McGranahan
- Cancer Research United Kingdom-University College London Lung Cancer Centre of Excellence
- Won-Chul Lee
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Julie George
- Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne
- Xiao Hu
- The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
- Yamei Chen
- The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
- Meijuan Wu
- The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital)
- Carmen Behrens
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Chi-Wan Chow
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Hoa H. N. Pham
- Department of Pathology, Nagasaki University Graduate school of Biomedical Sciences
- Junya Fukuoka
- Department of Pathology, Nagasaki University Graduate school of Biomedical Sciences
- Jia Wu
- Department of Image Physics, the University of Texas MD Anderson Cancer Center
- Edwin Roger Parra
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- Latasha D. Little
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Xingzhi Song
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Chang-Jiun Wu
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Lixia Diao
- Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center
- Qi Wang
- Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center
- Robert Cardnell
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Jing Wang
- Department of Bioinformatics and Computational Biology, the University of Texas MD Anderson Cancer Center
- Xiuning Le
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Don L. Gibbons
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- John V. Heymach
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- J. Jack Lee
- Department of Biostatistics, the University of Texas MD Anderson Cancer Center
- William N. William
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Chao Cheng
- Institute for Clinical and Translational Research, Baylor College of Medicine
- Bonnie Glisson
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Ignacio Wistuba
- Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, the University of Texas MD Anderson Cancer Center
- Roman K. Thomas
- Department of Translational Genomics, Medical Faculty, University of Cologne
- Alexandre Reuben
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Lauren A. Byers
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- Jianjun Zhang
- Department of Thoracic/Head and Neck Medical Oncology, the University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-26821-8
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Small-cell lung cancer (SCLC) is an aggressive disease with limited therapeutic options. Here the authors perform an immunogenomic analysis of limited-stage SCLC, revealing a homogeneous mutational landscape, but limited T-cell infiltration and a cold and heterogeneous T cell repertoire.
