Manipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast

Yiqi Jiang; Zhijiao Sun; Kexin Lu; Zeyu Wu; Hailong Xue; Li Zhu; Guosi Li; Yun Feng; Mianbin Wu; Jianping Lin; Jiazhang Lian; Lirong Yang

doi:10.1038/s41467-023-36007-z

Nature Communications (Jan 2023)

Manipulation of sterol homeostasis for the production of 24-epi-ergosterol in industrial yeast

Yiqi Jiang,
Zhijiao Sun,
Kexin Lu,
Zeyu Wu,
Hailong Xue,
Li Zhu,
Guosi Li,
Yun Feng,
Mianbin Wu,
Jianping Lin,
Jiazhang Lian,
Lirong Yang

Affiliations

Yiqi Jiang: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Zhijiao Sun: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Kexin Lu: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Zeyu Wu: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Hailong Xue: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Li Zhu: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Guosi Li: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Yun Feng: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Mianbin Wu: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Jianping Lin: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Jiazhang Lian: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University
Lirong Yang: Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University

DOI: https://doi.org/10.1038/s41467-023-36007-z
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 11

Abstract

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Brassinolide (BL) is one of the most active compounds among phytohormone brassinosteroids (BRs) and can be used for plant growth and development regulation. Here, the authors report the construction of an artificial pathway in baker’s yeast for scalable production of 24-epi-ergosterol, a precursor for BL semi-synthesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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