Nature Communications (Aug 2019)
Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes
- Hong Wang,
- Alexander K. Diaz,
- Timothy I. Shaw,
- Yuxin Li,
- Mingming Niu,
- Ji-Hoon Cho,
- Barbara S. Paugh,
- Yang Zhang,
- Jeffrey Sifford,
- Bing Bai,
- Zhiping Wu,
- Haiyan Tan,
- Suiping Zhou,
- Laura D. Hover,
- Heather S. Tillman,
- Abbas Shirinifard,
- Suresh Thiagarajan,
- Andras Sablauer,
- Vishwajeeth Pagala,
- Anthony A. High,
- Xusheng Wang,
- Chunliang Li,
- Suzanne J. Baker,
- Junmin Peng
Affiliations
- Hong Wang
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Alexander K. Diaz
- Integrated Biomedical Sciences Program, University of Tennessee Health Science Center
- Timothy I. Shaw
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Yuxin Li
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Mingming Niu
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Ji-Hoon Cho
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Barbara S. Paugh
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Yang Zhang
- Department of Tumor Cell Biology, St. Jude Children’s Research Hospital
- Jeffrey Sifford
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Bing Bai
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Zhiping Wu
- Department of Structural Biology, St. Jude Children’s Research Hospital
- Haiyan Tan
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Suiping Zhou
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Laura D. Hover
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Heather S. Tillman
- Department of Pathology, St. Jude Children’s Research Hospital
- Abbas Shirinifard
- Department of Information Sciences, St. Jude Children’s Research Hospital
- Suresh Thiagarajan
- Department of Diagnostic Imaging, St. Jude Children’s Research Hospital
- Andras Sablauer
- Department of Information Sciences, St. Jude Children’s Research Hospital
- Vishwajeeth Pagala
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Anthony A. High
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Xusheng Wang
- Center for Proteomics and Metabolomics, St. Jude Children’s Research Hospital
- Chunliang Li
- Department of Tumor Cell Biology, St. Jude Children’s Research Hospital
- Suzanne J. Baker
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Junmin Peng
- Department of Structural Biology, St. Jude Children’s Research Hospital
- DOI
- https://doi.org/10.1038/s41467-019-11661-4
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 15
Abstract
Multi-omic profiling is a powerful approach to dissecting molecular mechanisms in disease. Here the authors generate whole proteome, phosphoproteome and transcriptome profiles from two mouse models of high-grade glioma driven by different oncogenes, and validate identified master regulators with a CRISPR screen.
