Genome Biology (Aug 2019)

A statistical and biological response to an informatics appraisal of healthy aging gene signatures

  • James A. Timmons,
  • Iain J. Gallagher,
  • Sanjana Sood,
  • Bethan Phillips,
  • Hannah Crossland,
  • Robert Howard,
  • William E. Kraus,
  • Philip J. Atherton

DOI
https://doi.org/10.1186/s13059-019-1734-z
Journal volume & issue
Vol. 20, no. 1
pp. 1 – 4

Abstract

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Abstract Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings, below.