Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Mateo Murillo-León; Urs B. Müller; Ines Zimmermann; Shishir Singh; Pia Widdershooven; Cláudia Campos; Catalina Alvarez; Stephanie Könen-Waisman; Nahleen Lukes; Zsolt Ruzsics; Jonathan C. Howard; Martin Schwemmle; Tobias Steinfeldt

doi:10.1038/s41467-019-09200-2

Nature Communications (Mar 2019)

Molecular mechanism for the control of virulent Toxoplasma gondii infections in wild-derived mice

Mateo Murillo-León,
Urs B. Müller,
Ines Zimmermann,
Shishir Singh,
Pia Widdershooven,
Cláudia Campos,
Catalina Alvarez,
Stephanie Könen-Waisman,
Nahleen Lukes,
Zsolt Ruzsics,
Jonathan C. Howard,
Martin Schwemmle,
Tobias Steinfeldt

Affiliations

Mateo Murillo-León: Institute of Virology, Medical Center University of Freiburg
Urs B. Müller: Institute for Genetics, University of Cologne
Ines Zimmermann: Institute of Virology, Medical Center University of Freiburg
Shishir Singh: Institute of Virology, Medical Center University of Freiburg
Pia Widdershooven: Institute for Genetics, University of Cologne
Cláudia Campos: Fundação Calouste Gulbenkian, Instituto Gulbenkian de Ciencia
Catalina Alvarez: Fundação Calouste Gulbenkian, Instituto Gulbenkian de Ciencia
Stephanie Könen-Waisman: Department for Dermatology and Venereology, University Hospital of Cologne
Nahleen Lukes: Institute of Immunology, University Hospital Aachen
Zsolt Ruzsics: Institute of Virology, Medical Center University of Freiburg
Jonathan C. Howard: Fundação Calouste Gulbenkian, Instituto Gulbenkian de Ciencia
Martin Schwemmle: Institute of Virology, Medical Center University of Freiburg
Tobias Steinfeldt: Institute of Virology, Medical Center University of Freiburg

DOI: https://doi.org/10.1038/s41467-019-09200-2
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 15

Abstract

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Toxoplasma gondii virulence in wild-derived mice is restricted by Immunity-Related GTPases (IRG). Here, the authors show specific binding of the IRG tandem protein Irgb2-b1 with the virulence effector ROP5, and provide insights into how different ROP5 isoforms and IRG alleles shape virulence among T. gondii strains.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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