Frontiers in Genetics (Mar 2021)

Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis

  • Lu Han,
  • Dandan Li,
  • Yanwen Hang,
  • Xiaojuan Zong,
  • Jiashun Lv,
  • Xiaolu Bai,
  • Yi Lu,
  • Peng Zhang,
  • Meiling Zhou,
  • Zhaodi Wu,
  • Wei Hu

DOI
https://doi.org/10.3389/fgene.2021.632164
Journal volume & issue
Vol. 12

Abstract

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Circular RNAs (circRNAs) are novel non-coding RNAs, which show abnormal expression in several diseases, such as atherosclerosis (AS). The purpose of the present study was to reveal the association between hsa_circ_0004543 and AS. In the present study, hsa_circ_0004543 was overexpressed in human umbilical vein endothelial cells (HUVECs) induced by oxidized low-density lipoprotein (oxLDL). Inhibition of hsa_circ_0004543 expression facilitated the proliferation, migration, and invasion of HUVECs and significantly reduced their apoptotic rate following treatment with oxLDL. Furthermore, silencing of hsa_circ_0004543 activated the PI3K/AKT/NOS3 pathway in oxLDL-induced HUVECs. Collectively, these results demonstrated that hsa_circ_0004543 may play a vital role in the development of AS and affect the proliferation of HUVECs, providing a potential target for treating endothelial cell damage in AS.

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