THE LIPID PROFILE IN HEALTH AND DISEASE DONORS WITH DIFFERENT GENOTYPES FOR THE -308G>A POLYMORPHIC MARKER OF THE TNF GENE

Abstract

The effect of the substitution of guanine to adenine at position -308 in the TNF gene promoter on lipid profile in healthy donors and patients with essential hypertension (EH), rheumatoid arthritis (RA) and non-alcoholic steatohepatitis (NASH) was studied. The increase in tumor necrosis factor (TNFα) level in the blood plasma of patients as compared with donors in the control group was shown. It was accompanied by a change in triglycerides, cholesterol, high density and low density lipoproteins levels in blood plasma of patients with essential hypertension and non-alcoholic steatohepatitis. The effect of genotype for polymorphic marker -308G>A of the TNF gene on the level of total cholesterol in the blood plasma of patients with NASH and on the level of high density lipoprotein cholesterol of patients with EH was revealed. Significant differences in lipid levels in blood plasma of carriers of different genotypes of the studied markers in the control group and patients with RA were not found. The findings suggest that the -308G>A polymorphism of the TNF gene affects the lipid profile of blood plasma, however, does not clearly say what exactly the allele has a pro-atherogenic properties.

Keywords

• tumor necrosis factor alpha, gene polymorphism, lipids, essential hypertension, rheumatoid arthritis, non-alcoholic steatohepatitis