Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells

Chen Yijie; Sha Wenqi; Zhang Yifan; Kou Wanyi; Yang Liu; Guo Ruixin; Li Chenyang; Zhao Junjie; Wang Zhenghui

doi:10.1515/med-2024-1073

Open Medicine (Nov 2024)

Irisin-regulated lncRNAs and their potential regulatory functions in chondrogenic differentiation of human mesenchymal stem cells

Chen Yijie,
Sha Wenqi,
Zhang Yifan,
Kou Wanyi,
Yang Liu,
Guo Ruixin,
Li Chenyang,
Zhao Junjie,
Wang Zhenghui

Affiliations

Chen Yijie: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Sha Wenqi: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Zhang Yifan: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Kou Wanyi: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Yang Liu: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Guo Ruixin: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Li Chenyang: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Zhao Junjie: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi, 710004, People’s Republic of China
Wang Zhenghui: Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No.157 Xi Wu Road, Xi’anShaanxi, 710004, People’s Republic of China

DOI: https://doi.org/10.1515/med-2024-1073
Journal volume & issue: Vol. 19, no. 1
pp. 2041731420943839 – 73

Abstract

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Dysregulation of chondrogenic differentiation is associated with osteoarthritis (OA). The myokine irisin is beneficial in OA treatment; yet, the underlying mechanism is not fully understood. Long noncoding RNAs (lncRNAs) act as important regulators of chondrocyte differentiation. This study was conducted to address the role of lncRNAs in mediating irisin-induced chondrocyte differentiation.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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