PRC1-mediated epigenetic programming is required to generate the ovarian reserve

Mengwen Hu; Yu-Han Yeh; Yasuhisa Munakata; Hironori Abe; Akihiko Sakashita; So Maezawa; Miguel Vidal; Haruhiko Koseki; Neil Hunter; Richard M. Schultz; Satoshi H. Namekawa

doi:10.1038/s41467-022-31759-6

Nature Communications (Aug 2022)

PRC1-mediated epigenetic programming is required to generate the ovarian reserve

Mengwen Hu,
Yu-Han Yeh,
Yasuhisa Munakata,
Hironori Abe,
Akihiko Sakashita,
So Maezawa,
Miguel Vidal,
Haruhiko Koseki,
Neil Hunter,
Richard M. Schultz,
Satoshi H. Namekawa

Affiliations

Mengwen Hu: Department of Microbiology and Molecular Genetics, University of California, Davis
Yu-Han Yeh: Department of Microbiology and Molecular Genetics, University of California, Davis
Yasuhisa Munakata: Department of Microbiology and Molecular Genetics, University of California, Davis
Hironori Abe: Department of Microbiology and Molecular Genetics, University of California, Davis
Akihiko Sakashita: Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
So Maezawa: Division of Reproductive Sciences, Division of Developmental Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center
Miguel Vidal: Centro de Investigaciones Biológicas Margarita Salas, Department of Cellular and Molecular Biology
Haruhiko Koseki: Developmental Genetics Laboratory, RIKEN Center for Allergy and Immunology
Neil Hunter: Department of Microbiology and Molecular Genetics, University of California, Davis
Richard M. Schultz: Department of Biology, University of Pennsylvania
Satoshi H. Namekawa: Department of Microbiology and Molecular Genetics, University of California, Davis

DOI: https://doi.org/10.1038/s41467-022-31759-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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In humans, the ovarian reserve is maintained over decades by meiotic arrest of oocytes. Here the authors show that Polycomb Repressive Complex 1 (PRC1)-mediated epigenetic programming is essential for formation of ovarian reserve and thus female reproductive lifespan.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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