Scientific Reports (Jul 2021)
The impact of ossification spread on cervical spine function in patients with ossification of the posterior longitudinal ligament
- Keiichi Katsumi,
- Takashi Hirai,
- Toshitaka Yoshii,
- Satoshi Maki,
- Kanji Mori,
- Narihito Nagoshi,
- Soraya Nishimura,
- Kazuhiro Takeuchi,
- Shuta Ushio,
- Takeo Furuya,
- Kei Watanabe,
- Norihiro Nishida,
- Kota Watanabe,
- Takashi Kaito,
- Satoshi Kato,
- Katsuya Nagashima,
- Masao Koda,
- Kenyu Ito,
- Shiro Imagama,
- Yuji Matsuoka,
- Kanichiro Wada,
- Atsushi Kimura,
- Tetsuro Ohba,
- Hiroyuki Katoh,
- Yukihiro Matsuyama,
- Hiroshi Ozawa,
- Hirotaka Haro,
- Katsushi Takeshita,
- Masahiko Watanabe,
- Morio Matsumoto,
- Masaya Nakamura,
- Masashi Yamazaki,
- Atsushi Okawa,
- Yoshiharu Kawaguchi
Affiliations
- Keiichi Katsumi
- Spine Center, Department of Orthopedic Surgery, Niigata Central Hospital
- Takashi Hirai
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
- Toshitaka Yoshii
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
- Satoshi Maki
- Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine
- Kanji Mori
- Department of Orthopaedic Surgery, Shiga University of Medical Science
- Narihito Nagoshi
- Department of Orthopaedic Surgery, Keio University, School of Medicine
- Soraya Nishimura
- Department of Orthopaedic Surgery, Keio University, School of Medicine
- Kazuhiro Takeuchi
- Department of Orthopedic Surgery, National Hospital Organization Okayama Medical Center
- Shuta Ushio
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
- Takeo Furuya
- Department of Orthopaedic Surgery, Chiba University Graduate School of Medicine
- Kei Watanabe
- Department of Orthopedic Surgery, Niigata University Medical and Dental General Hospital
- Norihiro Nishida
- Department of Orthopaedic Surgery, Yamaguchi University Graduate School of Medicine
- Kota Watanabe
- Department of Orthopaedic Surgery, Keio University, School of Medicine
- Takashi Kaito
- Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine
- Satoshi Kato
- Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University
- Katsuya Nagashima
- Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba
- Masao Koda
- Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba
- Kenyu Ito
- Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine
- Shiro Imagama
- Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine
- Yuji Matsuoka
- Department of Orthopedic Surgery, Tokyo Medical University
- Kanichiro Wada
- Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine
- Atsushi Kimura
- Department of Orthopaedic Surgery, Jichi Medical University
- Tetsuro Ohba
- Department of Orthopedic Surgery, University of Yamanashi
- Hiroyuki Katoh
- Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine
- Yukihiro Matsuyama
- Department of Orthopedic Surgery, Hamamatsu University School of Medicine
- Hiroshi Ozawa
- Department of Orthopaedic Surgery, Tohoku Medical and Pharmaceutical University
- Hirotaka Haro
- Department of Orthopedic Surgery, University of Yamanashi
- Katsushi Takeshita
- Department of Orthopaedic Surgery, Jichi Medical University
- Masahiko Watanabe
- Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine
- Morio Matsumoto
- Department of Orthopaedic Surgery, Keio University, School of Medicine
- Masaya Nakamura
- Department of Orthopaedic Surgery, Keio University, School of Medicine
- Masashi Yamazaki
- Department of Orthopaedic Surgery, Faculty of Medicine, University of Tsukuba
- Atsushi Okawa
- Department of Orthopedic Surgery, Tokyo Medical and Dental University
- Yoshiharu Kawaguchi
- Department of Orthopedic Surgery, Faculty of Medicine, University of Toyama
- DOI
- https://doi.org/10.1038/s41598-021-93602-0
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 9
Abstract
Abstract Ossification of the posterior longitudinal ligament (OPLL) is a progressive disease. The bridging of ossified lesions to the vertebral body gradually increases, thereby decreasing the mobility of the cervical spine; thus, cervical spine function may decrease over time. However, cervical spine function in patients with cervical OPLL has not been evaluated in large prospective studies. Therefore, we conducted a prospective multicenter study to clarify whether ossification spread can influence cervical spine function and quality of life (QOL) in patients with cervical OPLL. In total, 238 patients (162 men, 76 women; mean age, 63.9 years) were enrolled from 16 institutions. Each patient underwent whole spine computed tomography and was evaluated for cervical spine function and QOL using the Japanese Orthopaedic Association Cervical Myelopathy Evaluation Questionnaire (JOACMEQ). In the multivariate regression analysis, a higher neck VAS score and a larger number of bridge formations of OPLL in the whole spine were significant predictors of adverse outcomes related to cervical spine function. This is the first prospective multicenter study to reveal the impact of ossification spread on cervical spine function. These findings are important to understand the natural course of OPLL and can serve as controls when evaluating postoperative cervical spine function.
