Molecular Interactions in the Development of Brain Metastases

Abstract

Brain metastases are a much-feared complication of cancer. The development of brain metastases requires a malignant cell to acquire characteristics that facilitate dissemination away from the primary site, entrance into the nervous system, and establishment in the brain. This review summarizes recent work focused on the molecular derangements leading to brain metastases and outlines areas in need of greater understanding.

Keywords

• CNS metastasis
• metastatic cascade
• vascular co-option
• dormancy