Comparative study on genotoxicity methods between OECD Test guidelines and GB15193

Abstract

ObjectiveThe purpose of this study is to compare genotoxicity methods between OECD test guidelines and China food safety standards（GB15193）．MethodsMain parameters of related genotoxicity methods in OECD Testing Guidelines and GB 15193 standards were compared and analyzed．ResultsThe methodology system of genotoxicity tests was similar between OECD and GB15193. However， there were some different recommendations in some parameters including cells/animal selection， treatment concentrations/dose selection and evaluation of results， etc.ConclusionAs a set of internationally recognized standards， OECD test guidelines can be beneficial to the improvement of GB15193 standards on genotoxicity.

Keywords

• oecd
• gb15193
• genotoxicity
• national food safety standard
• test guideline