Nature Communications (Apr 2016)
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis
- Yuhsuke Ohmi,
- Wataru Ise,
- Akira Harazono,
- Daisuke Takakura,
- Hidehiro Fukuyama,
- Yoshihiro Baba,
- Masashi Narazaki,
- Hirofumi Shoda,
- Nobunori Takahashi,
- Yuki Ohkawa,
- Shuting Ji,
- Fumihiro Sugiyama,
- Keishi Fujio,
- Atsushi Kumanogoh,
- Kazuhiko Yamamoto,
- Nana Kawasaki,
- Tomohiro Kurosaki,
- Yoshimasa Takahashi,
- Koichi Furukawa
Affiliations
- Yuhsuke Ohmi
- Department of Biochemistry II, Nagoya University Graduate School of Medicine
- Wataru Ise
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
- Akira Harazono
- Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
- Daisuke Takakura
- Laboratory of Proteome Science, Graduate School of Medical Life Science, Yokohama City University
- Hidehiro Fukuyama
- Laboratory for Lymphocyte Differentiation, RIKEN Center for Integrative Medical Sciences
- Yoshihiro Baba
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
- Masashi Narazaki
- Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine
- Hirofumi Shoda
- Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo
- Nobunori Takahashi
- Department of Orthopedics, Nagoya University Graduate School of Medicine
- Yuki Ohkawa
- Department of Biochemistry II, Nagoya University Graduate School of Medicine
- Shuting Ji
- Department of Biochemistry II, Nagoya University Graduate School of Medicine
- Fumihiro Sugiyama
- Laboratory Animal Resource Center, University of Tsukuba
- Keishi Fujio
- Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo
- Atsushi Kumanogoh
- Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Graduate School of Medicine
- Kazuhiko Yamamoto
- Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo
- Nana Kawasaki
- Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
- Tomohiro Kurosaki
- Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center and Graduate School of Frontier Biosciences, Osaka University
- Yoshimasa Takahashi
- Department of Immunology, National Institute of Infectious Diseases
- Koichi Furukawa
- Department of Biochemistry II, Nagoya University Graduate School of Medicine
- DOI
- https://doi.org/10.1038/ncomms11205
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 12
Abstract
Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice.
