Acta Biomedica Scientifica (Sep 2012)
PROSPECTIVE GROWTH STIMULATORS OF BACTERIAL MASS OF STAPHYLOCOCCUS AUREUS (TO PRODUCE PROTEIN А)
Abstract
The influence of 2-hydroxyethylammonium salts of biologically active arylsulfanylacetic acids on the yield of bacterial mass of Staphylococcus aureus (strain 209), biomass of Merezhkovsky's bacteria (Salmonella typhi spermophilorum.) and E. coli (E. coli М-17) has bee studied for the first time. The introduction of growth stimulators (in concentration of 10-3-10-8 wt. %) into nutrient medium increases the yield of microorganisms bacterial mass: Staphilococcus aureus by 32-40 %, Merezhkovsky's bacteria Salmonella typhi spermophilorum. by 47,5-140,4 %, E. coli by 11,4-59,4 %. The increase of yield of the microorganisms biomass reached by application of the growth stimulators opens the route to their utilization in large-scale processes of Staphilococcus aureus cultivation for the production of valuable protein А, biopreparations, diagnostic agents, serum, vaccines, probiotic drugs as well as for the struggle with rodents (plaque carriers, pests).
