Nature Communications (Nov 2020)

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids

  • Jing Zhao,
  • Yuan Fu,
  • Yu Yamazaki,
  • Yingxue Ren,
  • Mary D. Davis,
  • Chia-Chen Liu,
  • Wenyan Lu,
  • Xue Wang,
  • Kai Chen,
  • Yesesri Cherukuri,
  • Lin Jia,
  • Yuka A. Martens,
  • Lucy Job,
  • Francis Shue,
  • Thanh Thanh Nguyen,
  • Steven G. Younkin,
  • Neill R. Graff-Radford,
  • Zbigniew K. Wszolek,
  • David A. Brafman,
  • Yan W. Asmann,
  • Nilüfer Ertekin-Taner,
  • Takahisa Kanekiyo,
  • Guojun Bu

DOI
https://doi.org/10.1038/s41467-020-19264-0
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

Read online

APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phenotype.