In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation

Eliana Moreira Tavares; William Douglass Wright; Wolf-Dietrich Heyer; Eric Le Cam; Pauline Dupaigne

doi:10.1038/s41467-019-12082-z

Nature Communications (Sep 2019)

In vitro role of Rad54 in Rad51-ssDNA filament-dependent homology search and synaptic complexes formation

Eliana Moreira Tavares,
William Douglass Wright,
Wolf-Dietrich Heyer,
Eric Le Cam,
Pauline Dupaigne

Affiliations

Eliana Moreira Tavares: Genome Maintenance and Molecular Microscopy UMR8126 CNRS, Université Paris-Sud, Université Paris-Saclay, Gustave Roussy
William Douglass Wright: Department of Microbiology and Molecular Genetics, University of California, Davis
Wolf-Dietrich Heyer: Department of Microbiology and Molecular Genetics, University of California, Davis
Eric Le Cam: Genome Maintenance and Molecular Microscopy UMR8126 CNRS, Université Paris-Sud, Université Paris-Saclay, Gustave Roussy
Pauline Dupaigne: Genome Maintenance and Molecular Microscopy UMR8126 CNRS, Université Paris-Sud, Université Paris-Saclay, Gustave Roussy

DOI: https://doi.org/10.1038/s41467-019-12082-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Homologous recombination uses a template to accurately repair DNA double-strand breaks and stalled replication forks to maintain genome stability. Here authors use electron microscopy to investigate the role of Rad54 in homology search and synaptic complex formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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