International Journal of Public Health (Oct 2023)
Effect of Annual Influenza Vaccination on the Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in Taiwan
- Hung-Chang Jong,
- Jing-Quan Zheng,
- Jing-Quan Zheng,
- Jing-Quan Zheng,
- Cai-Mei Zheng,
- Cai-Mei Zheng,
- Cai-Mei Zheng,
- Cheng-Hsin Lin,
- Cheng-Hsin Lin,
- Cheng-Hsin Lin,
- Chun-Chih Chiu,
- Chun-Chih Chiu,
- Chun-Chih Chiu,
- Min-Huei Hsu,
- Min-Huei Hsu,
- Yu-Ann Fang,
- Yu-Ann Fang,
- Yu-Ann Fang,
- Wen-Rui Hao,
- Wen-Rui Hao,
- Wen-Rui Hao,
- Chun-Chao Chen,
- Chun-Chao Chen,
- Chun-Chao Chen,
- Chun-Chao Chen,
- Tsung Yeh Yang,
- Tsung Yeh Yang,
- Tsung Yeh Yang,
- Kang-Yun Lee,
- Kang-Yun Lee,
- Kang-Yun Lee,
- Ju-Chi Liu,
- Ju-Chi Liu,
- Ju-Chi Liu
Affiliations
- Hung-Chang Jong
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Jing-Quan Zheng
- Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Jing-Quan Zheng
- Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Jing-Quan Zheng
- Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Cai-Mei Zheng
- Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Cai-Mei Zheng
- Division of Nephrology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Cai-Mei Zheng
- Taipei Medical University Research Center of Urology and Kidney, Taipei Medical University, Taipei, Taiwan
- Cheng-Hsin Lin
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Cheng-Hsin Lin
- Division of Cardiovascular Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Cheng-Hsin Lin
- 0Division of Cardiovascular Surgery, Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Chun-Chih Chiu
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Chun-Chih Chiu
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Chun-Chih Chiu
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Min-Huei Hsu
- 2Graduate Institute of Data Science, College of Management, Taipei Medical University, Taipei, Taiwan
- Min-Huei Hsu
- 3Department of Neurosurgery, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
- Yu-Ann Fang
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Yu-Ann Fang
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Yu-Ann Fang
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Wen-Rui Hao
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Wen-Rui Hao
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Wen-Rui Hao
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Chun-Chao Chen
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Chun-Chao Chen
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Chun-Chao Chen
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Chun-Chao Chen
- 4Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Tsung Yeh Yang
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Tsung Yeh Yang
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Tsung Yeh Yang
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Kang-Yun Lee
- Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Kang-Yun Lee
- Division of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Kang-Yun Lee
- Division of Pulmonary Medicine, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- Ju-Chi Liu
- Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan
- Ju-Chi Liu
- Taipei Heart Institute, Taipei Medical University, Taipei, Taiwan
- Ju-Chi Liu
- 1Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
- DOI
- https://doi.org/10.3389/ijph.2023.1605370
- Journal volume & issue
-
Vol. 68
Abstract
Objectives: Lung cancer is a main contributor to all newly diagnosed cancers worldwide. The chemoprotective effect of the influenza vaccine among patients with hypertension remains unclear.Methods: A total of 37,022 patients with hypertension were retrospectively enrolled from the Taiwan National Health Insurance Research Database. These patients were further divided into a vaccinated group (n = 15,697) and an unvaccinated group (n = 21,325).Results: After adjusting for sex, age, comorbidities, medications, level of urbanization and monthly income, vaccinated patients had a significantly lower risk of lung cancer occurrence than unvaccinated patients (adjusted hazard ratio [aHR]: 0.56, 95% confidence interval [CI]: 0.47–0.67). A potential protective effect was observed for both sexes and in the elderly age group. With a greater total number of vaccinations, a potentially greater protective effect was observed (aHR: 0.75, 95% CI 0.60–0.95; aHR: 0.66, 95% CI: 0.53–0.82; aHR: 0.26, 95% CI: 0.19–0.36, after receiving 1, 2–3 and ≥4 vaccinations, respectively).Conclusion: Influenza vaccination was associated with a lower risk of lung cancer among patients with hypertension. The potentially chemoprotective effect appeared to be dose dependent.
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