Iodophor-/H₂O₂-Mediated 2-Sulfonylation of Indoles and <i>N</i>-Methylpyrrole in Aqueous Phase

Abstract

A convenient and efficient strategy for the preparation of 2-sulfonylindoles has been achieved through iodophor-/H2O2-mediated 2-sulfonylation of indoles with readily available sulfonyl hydrazides in the aqueous phase. Iodophor is commercially available and serves as the green catalyst and aqueous phase. A series of 2-sulfonylated products from indoles and N-methylpyrrole were synthesized in moderate yields in only 10 min. Control experiments were also conducted to reveal the mechanism of action. This method is environment friendly, easy to operate and suitable for a wide range of substrates.

Keywords

• iodophor
• 2-sulfonylation
• indoles
• sulfonyl hydrazides