Model for studying anti- allergic drugs for allergic conjunctivitis in animals

Abstract

Allergic conjunctivitis (AC), which is characterized by ocular itching, hyperemia, and edema, deteriorates quality of life. In this study, effects of anti-allergic drugs were evaluated by assessing eye-scratching behavior, the number of eosinophils in conjunctiva epithelial tissues, and concentrations of chemical mediators in the tears of the guinea pig model of ovalbumin (OA)-induced AC.

Keywords

• Allergic conjunctivitis
• Anti-allergic drugs
• Histamine
• Substance P