The expression of DNAJB9 in normal human astrocytes is more sensitive to nanographene oxide than in glioblastoma cells

Abstract

Objective. Nanographene oxide (nGO) nanoparticles (NPs) have unique properties and are widely used in various fields, including biomedicine. These NPs, however, also exhibit toxic ef­fects and therefore, the understanding of the molecular mechanism of nGO toxicity is very im­portant mainly for the nanomedicine, especially the cancer therapy. This study aimed to examine the impact of nGO NPs on the expression of genes associated with endoplasmic reticulum (ER) stress, proliferation, and cancerogenesis in both normal human astrocytes and U87MG glioblas­toma cells.

Keywords

• nanographene oxide
• dnajb9
• ddit3
• edem1
• idh2
• mrna expression
• geno-toxicity
• ern1 knockdown
• normal human astrocytes
• glioblastoma cells