Different causes of early and late-onset post transplant lymphoproliferative disorder in kidney transplantation patients after 2000

Abstract

Summary: Background: The purpose of this study was to analyze the link between PTLD incidence and its occurrence time in patients at a single center in comparable medical environments after 2000. Methods: Retrospectively, total 3305 kidney transplantation patients medical data were analyzed. Patients were divided into two groups based on the period from the day of kidney transplantation to the day of PTLD diagnosis. Early-onset was defined as PTLD development within two years after transplantation, whereas all other cases were categorized as late-onset PTLD. Results: In the early-onset group, young age (0–19 years) was confirmed as a risk factor for PTLD incidence (HR 1.49, p = 0.038). In the late-onset group, history of anti-rejection therapy was confirmed as a risk factor (HR 1.32, p = 0.031). Overall survival rates were not significantly different between the two groups (p = 0.556). Graft survival rates were also not different between the two groups (p = 0.549). Conclusion: When patients with PTLD were classified into early-onset group and late-onset group at two years, overall survival and graft survival were comparable. And patients with early-onset PTLD are more likely to be associated with EBV, the late-onset patients are more likely to be immunosuppressed. Keywords: Kidney transplantation, Risk factors, Immunocompromised host